The association between high oral intake of acrylamide and risk of breast cancer: An updated systematic review and meta-analysis

Background: The consumption of acrylamide through different types of food products can be correlated with cancer risk. In this study, the correlation between high oral intake of acrylamide and breast cancer risk was assessed with the aid of meta-analysis. Scope and approach: Some of the databases such as Web of Science, Scopus, PubMed, and Embase were screened to up to September 2019 in order to retrieve the related articles. Therefore, ten articles with 57 studies (data-reports) were included in the current meta-analysis. Also, the relative risks (RRs) of breast cancer for high vs low intake acrylamide were calculated by a fixed-effects model (FEM). Also, the publication bias was assessed using Begg and Egger tests. Key findings and conclusions: The pooled relative risk (RRs) of breast cancer was significance (RR = 0.95; 95%CI: 0.92-0.97) with low heterogeneity (12: 0.0%, P-value: 0.994). Significant RRs in all women subgroup was observed as a marginally significant (0.95, 95%CI: 0.92-0.98), however, RRs was not significant in never-smoking women subgroup (0.93, 95%CI: 0.86-1.01). Additionally, no significant RRs were found in all hormone receptors. Moreover, no significant difference among RRs in body mass index (BMI) status subgroups (BMI < 12 kg/m(2) (0.93; 95%CI: 0.83-1.02) and BMI >= 12 kg/m(2) (0.97; 95%CI: 0.91-1.03) and coffee consumption (0.96; 95%CI: 0.84-1.09)) were noted. The high intake acrylamide can reduces the risk of breast cancer as marginal significantly. Therefore, in order to assess the related mechanisms, further studies are recommended.