Nickel(II) affects poly(ADP-ribose) polymerase-mediated DNA repair in normal and cancer cells

被引：0
|
作者：
Wozniak, K [1 ]
Czechowska, A [1 ]
Blasiak, J [1 ]
机构：
[1] Univ Lodz, Dept Mol Genet, PL-90237 Lodz, Poland
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES | 2006年 / 61卷 / 1-2期
关键词：
DNA repair; nickel; poly(ADP-ribose) polymerase;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nickel(II) can be genotoxic, but the mechanism of its genotoxicity is not fully understood and the process of DNA repair may be considered as its potential target. We studied the effect of nickel chloride on the poly (ADP-ribose) polymerase (PARP)-mediated repair of DNA damaged by gamma-radiation and idarubicin with the alkaline comet assay in normal and cancer cells. Our results indicate that nickel chloride at very low, non-cytotoxic concentration of 1 mu M can affect PARP-mediated DNA repair of lesions evoked by idarubicin and gamma-radiation. We also suggest that in the quiescent lymphocytes treated with gamma-radiation, nickel(II) could interfere with DNA repair process independent of PARP.
引用
收藏
页码：142 / 148
页数：7
相关论文
共 50 条
  • [31] DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines
    Trucco, C
    Oliver, FJ
    de Murcia, G
    Ménissier-de Murcia, J
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (11) : 2644 - 2649
  • [32] NAD+ influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death
    Okuda, Hiroto
    Nishida, Kentaro
    Higashi, Youichirou
    Nagasawa, Kazuki
    [J]. LIFE SCIENCES, 2013, 92 (13) : 808 - 814
  • [33] A role for poly (ADP-ribose) polymerase in telomere-mediated DNA damage responses
    Backvall, H
    Eller, MS
    Gilchrest, BA
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (04) : A78 - A78
  • [34] DNA STRAND BREAK-MEDIATED PARTITIONING OF POLY(ADP-RIBOSE) POLYMERASE FUNCTION
    PANZETER, PL
    ALTHAUS, FR
    [J]. BIOCHEMISTRY, 1994, 33 (32) : 9600 - 9605
  • [35] Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
    Fisher, Anna E. O.
    Hochegger, Helfrid
    Takeda, Shunichi
    Caldecott, Keith W.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (15) : 5597 - 5605
  • [36] The role of poly(ADP-ribose) polymerase in response to DNA damage
    Ruscetti, T
    Peterson, SR
    Lehnert, BE
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 2063 - 2063
  • [37] Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy
    Gourley, Charlie
    Balmana, Judith
    Ledermann, Jonathan A.
    Serra, Violeta
    Dent, Rebecca
    Loibl, Sibylle
    Pujade-Lauraine, Eric
    Boulton, Simon J.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (25) : 2257 - +
  • [38] Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1
    Vodenicharov, MD
    Sallmann, FR
    Satoh, MS
    Poirier, GG
    [J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (20) : 3887 - 3896
  • [39] POSSIBLE INVOLVEMENT OF THE DNA-REPAIR ENZYME POLY (ADP-RIBOSE) POLYMERASE (PARP) IN THE TREATMENT OF CANCER BY HYPERTHERMIA
    SIMPSON, TA
    LARUSSA, PG
    MULLINS, DW
    CONLEY, SC
    DAUGHERTY, JP
    [J]. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 49 - 49
  • [40] Poly(ADP-ribose) polymerase: A guardian of the genome that facilitates DNA repair by protecting against DNA recombination
    Satadal Chatterjee
    Sosamma J. Berger
    Nathan A. Berger
    [J]. Molecular and Cellular Biochemistry, 1999, 193 : 23 - 30
12345