Nickel(II) affects poly(ADP-ribose) polymerase-mediated DNA repair in normal and cancer cells

被引：0
|
作者：
Wozniak, K [1 ]
Czechowska, A [1 ]
Blasiak, J [1 ]
机构：
[1] Univ Lodz, Dept Mol Genet, PL-90237 Lodz, Poland
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES | 2006年 / 61卷 / 1-2期
关键词：
DNA repair; nickel; poly(ADP-ribose) polymerase;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nickel(II) can be genotoxic, but the mechanism of its genotoxicity is not fully understood and the process of DNA repair may be considered as its potential target. We studied the effect of nickel chloride on the poly (ADP-ribose) polymerase (PARP)-mediated repair of DNA damaged by gamma-radiation and idarubicin with the alkaline comet assay in normal and cancer cells. Our results indicate that nickel chloride at very low, non-cytotoxic concentration of 1 mu M can affect PARP-mediated DNA repair of lesions evoked by idarubicin and gamma-radiation. We also suggest that in the quiescent lymphocytes treated with gamma-radiation, nickel(II) could interfere with DNA repair process independent of PARP.
引用
收藏
页码：142 / 148
页数：7
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