Automated hemodynamic regulation with model predictive control

A multiple model adaptive predictive controller is designed to regulate mean arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive drugs. The algorithm uses a multiple model adaptive approach in a model predictive control framework to account for inter- and intra-patient variability and explicitly handle drug rate constraints, The controller is evaluated on canines that were pharmacologically altered to exhibit symptoms of hypertension and depressed cardiac output.