The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data

被引：149
|
作者：
Jungo, Florence [1 ]
Bougueleret, Lydie [1 ]
Xenarios, Ioannis [1 ,2 ]
Poux, Sylvain [1 ]
机构：
[1] Ctr Med Univ Geneva, Swiss Inst Bioinformat, CH-1211 Geneva 4, Switzerland
[2] Swiss Inst Bioinformat, Vital IT Grp, CH-1015 Lausanne, Switzerland
来源：
TOXICON | 2012年 / 60卷 / 04期
基金：
美国国家卫生研究院;
关键词：
UniProtKB/Swiss-Prot Tox-Prot program; Database; Curation; Venom protein; Animal toxin; Bioinformatics; POSTTRANSLATIONAL MODIFICATIONS; NOMENCLATURE; ANNOTATION; EVOLUTION; COMPLEXITY; SEQUENCES; KNOWLEDGE; CDNA;
D O I：
10.1016/j.toxicon.2012.03.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Animal toxins are of interest to a wide range of scientists, due to their numerous applications in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser extent the development of new performing tools in transcriptomics and proteomics, has led to an increase in toxin discovery. In this context, providing publicly available data on animal toxins has become essential. The UniProtKB/Swiss-Prot Tox-Prot program (http://www.uniprot.org/program/Toxins) plays a crucial role by providing such an access to venom protein sequences and functions from all venomous species. This program has up to now curated more than 5000 venom proteins to the high-quality standards of UniProtKB/Swiss-Prot (release 2012_02). Proteins targeted by these toxins are also available in the knowledgebase. This paper describes in details the type of information provided by UniProtKB/Swiss-Prot for toxins, as well as the structured format of the knowledgebase. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：551 / 557
页数：7
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