Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin

被引：10

作者：

Ju, Hai-Peng ^{[1
,2
]}

Wang, Yi-Zhou ^{[1
,2
]}

You, Jing ^{[1
,2
]}

Hou, Xi-Miao ^{[3
]}

Xi, Xu-Guang ^{[3
]}

Dou, Shuo-Xing ^{[1
,2
]}

Li, Wei ^{[1
,2
]}

Wang, Peng-Ye ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Inst Phys, 8 3rd South St, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Key Lab Soft Matter Phys, Inst Phys, 8 3rd South St, Beijing 100190, Peoples R China

[3] Northwest A&F Univ, Sch Life Sci, 3 Taicheng Rd, Yangling 712100, Peoples R China

来源：

ACS OMEGA | 2016年 / 1卷 / 02期

关键词：

MAGNETIC TWEEZERS; ANTICANCER DRUGS; SMALL-MOLECULE; C-MYC; DNA; STABILITY; PROTEINS; FLUORESCENCE; SEQUENCES; ADHESION;

D O I：

10.1021/acsomega.6b00044

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration.

引用

页码：244 / 250

页数：7

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