Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients

被引：38
|
作者：
Rizzo, G. [1 ,2 ]
Manners, D. [1 ,3 ]
Vetrugno, R. [2 ]
Tonon, C. [1 ]
Malucelli, E. [1 ]
Plazzi, G. [2 ]
Marconi, S. [2 ]
Pizza, F. [2 ]
Testa, C. [1 ]
Provini, F. [2 ]
Montagna, P. [2 ]
Lodi, R. [1 ]
机构：
[1] Univ Bologna, Funct MR Unit, Dept Internal Med Aging & Nephrol, I-40138 Bologna, Italy
[2] Univ Bologna, Inst Neurol Sci, I-40138 Bologna, Italy
[3] Univ Bologna, Dept Histol Embryol & Appl Biol, I-40138 Bologna, Italy
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2012年 / 19卷 / 07期
关键词：
diffusion tensor imaging; restless legs syndrome; statistical parametric mapping; tract-based spatial statistics; voxel-based morphometry; MATTER ALTERATIONS;
D O I：
10.1111/j.1468-1331.2011.03604.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). Methods: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. Results: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. Conclusions: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.
引用
收藏
页码：1045 / 1049
页数：5
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