Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression

被引：27

作者：

Ou, Yunwei ^{[1
,2
,3
,4
,5
,6
,10
]}

Zhao, Zitong ^{[2
,3
,4
]}

Zhang, Weimin ^{[2
,3
,4
]}

Wu, Qingnan ^{[2
,3
,4
]}

Wu, Chuanyue ^{[7
,8
,9
]}

Liu, Xuefeng ^{[2
,3
,4
]}

Fu, Ming ^{[2
,3
,4
]}

Ji, Nan ^{[1
]}

Wang, Dan ^{[1
]}

Qiu, Jiaji ^{[1
]}

Zhang, Liwei ^{[1
]}

Yu, Chunjiang ^{[6
]}

Song, Yongmei ^{[2
,3
,4
]}

Zhan, Qimin ^{[2
,3
,4
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[3] Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China

[6] Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China

[7] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15261 USA

[8] South Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Peoples R China

[9] South Univ Sci & Technol China, Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China

[10] China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 46期

基金：

中国国家自然科学基金;

关键词：

EGFR; glioma; Kindlin-2; transcription; GROWTH-FACTOR RECEPTOR; GENE-EXPRESSION; BREAST-CANCER; NUCLEAR-LOCALIZATION; SIGNALING PATHWAYS; GASTRIC-CANCER; INVASION; PROMOTES; CELLS; GLIOBLASTOMA;

D O I：

10.18632/oncotarget.12439

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kindlin-2 promotes carcinogenesis through regulation of cell-cell and cell-extracellular matrix adhesion. However, the role of Kindlin-2 in glioma has not been elucidated. We investigated Kindlin-2 expression in 188 human glioma tissue samples. High Kindlin-2 expression was correlated with high pathological grade and a worse prognosis. Kindlin-2 promoted glioma cell motility and proliferation both in vitro and in vivo. Importantly, Kindlin-2 activated the EGFR pathway and increased EGFR mRNA levels. In addition to up-regulating Y-box binding protein-1 (YB-1) and beta-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and beta-catenin that bound to the EGFR promoter and enhanced transcription. The beta-catenin/YB-1/EGFR pathway was required for Kindlin-2-mediated functions. Our data provide a better understanding of the mechanisms underlying glioma progression, and suggest that Kindlin-2 may be a biomarker and therapeutic target in glioma.

引用

页码：74872 / 74885

页数：14

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