Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing

被引：33
|
作者：
Kweon, HaeYong [1 ]
Yeo, Joo-hong [1 ]
Lee, Kwang-gill [1 ]
Lee, Hyun Chul [2 ,3 ]
Na, Hee Sam [2 ,3 ]
Won, Young Ho [4 ]
Cho, Chong Su [5 ]
机构：
[1] Natl Inst Agr Sci & Technol, Appl Sericulture & Apiculture Div, Suwon 441100, South Korea
[2] Chonnam Natl Univ, Dept Microbiol, Sch Med, Kwangju, South Korea
[3] Chonnam Natl Univ, Res Inst Med Sci, Sch Med, Kwangju, South Korea
[4] Chonnam Natl Univ, Dept Dermatol, Sch Med, Kwangju, South Korea
[5] Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151742, South Korea
来源：
BIOMEDICAL MATERIALS | 2008年 / 3卷 / 03期
关键词：
D O I：
10.1088/1748-6041/3/3/034115
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.
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页数：5
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