Thermo- and pH-responsive gels for application in colon delivery systems

被引：24
|
作者：
Yoshida, M
Asano, M
Suwa, T
Katakai, R
机构：
[1] Takasaki Radiat Chem Res Estab, Japan Atom Energy Res Inst, Dept Mat Dev, Gunma 3701292, Japan
[2] Gunma Univ, Fac Engn, Dept Chem, Gunma 3768515, Japan
来源：
RADIATION PHYSICS AND CHEMISTRY | 1999年 / 55卷 / 5-6期
关键词：
D O I：
10.1016/S0969-806X(99)00210-8
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Swelling-controlled drug delivery copolymer gels were synthesized by introducing thermo- and pH-responsive methacryloyl-glycine (MA-Gly) of pi-I-responsive methacrylic acid (MA-Ac) into thermo-responsive acryloyl-L-proline ethyl ester (A-ProOEt). The threshold of swelling for copolymer gels consisting of A-ProOEt/MA-Gly and A-ProOEt/MA-Ac with a composition of 40/60 mol% was found to be pH 3.0 and pH 5.5, respectively, in buffer solutions at 37 degrees C. The diffusion characteristics of 2-(3-benzoylphenyl)propionic acid (ketoprofen) from such copolymer gels were evaluated in buffer solutions at pHs more than 5.5, and it was found that A-ProOEt/MA-Gly gel possessed a Case II transport, while the A-ProOEt/MA-Ac gel exhibited a non-Fickian (or anomalous) diffusion behavior under the same conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：677 / 680
页数：4
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