Effect of hydroxyurea therapy on resting energy expenditure in children with sickle cell disease

被引：13
|
作者：
Fung, EB
Barden, EM
Kawchak, DA
Zemel, BS
Ohene-Frempong, K
Stallings, VA
机构：
[1] Univ Penn, Sch Med, Dept Pediat, Childrens Hosp Philadelphia,Div Gastroenterol & N, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Pediat, Childrens Hosp Philadelphia,Div Hematol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2001年 / 23卷 / 09期
关键词：
sickle cell anemia; resting energy expenditure; children; hydroxyurea; nutrition; growth;
D O I：
10.1097/00043426-200112000-00010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Effects of hydroxyurea therapy on resting energy expenditure (REE) in children with sickle cell disease have not been evaluated. Eight children with sickle cell disease were examined before hydroxyurea therapy and again 6.9 +/- 3.5 months after hydroxyurea initiation. Resting energy expenditure, dietary intake, and growth were assessed. In six children, baseline REE was elevated, and REE decreased an average of 17% with hydroxyurea. This was associated with a significant increase in fetal hemoglobin. These pilot data suggest that hydroxyurea may curtail the hypermetabolic state observed in children with sickle cell disease and may offer a clinically important secondary benefit.
引用
收藏
页码：604 / 608
页数：5
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