Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones

被引：42
|
作者：
Dharmaratne, HRW
Tan, GT
Marasinghe, GPK
Pezzuto, JM
机构：
[1] Inst Fundamental Studies, Nat Prod Programme, Kandy, Sri Lanka
[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Programme Collaborat Res Pharmceut Sci, Chicago, IL USA
来源：
PLANTA MEDICA | 2002年 / 68卷 / 01期
关键词：
D O I：
10.1055/s-2002-20058
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC50 values of 19.3 and 11.7 muM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).
引用
收藏
页码：86 / 87
页数：2
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