Microwave-assisted synthesis of substituted pyrazoles and pyrazolo [3,4-d]thiopyrimidines

被引：14

作者：

Heravi, MM ^{[1
]}

Nami, N ^{[1
]}

Seifi, N ^{[1
]}

Oskooie, HA ^{[1
]}

Hekmatshoar, R ^{[1
]}

机构：

[1] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2006年 / 181卷 / 03期

关键词：

ethylcyanoacetate; malononitrile; pyrazolo[3,4-d]thiopyrimidine; triethyl orthoacetate; triethyl orthoformate;

D O I：

10.1080/10426500500269646

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ethyl(ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile were synthesized from the reaction of malononitrile or ethylcyanoacetate with triethyl ortho-formate or orthoacetate in N, N-dimethylacetamide under microwave irradiation. In a similar manner, substituted pyrazoles were synthesized from the reaction of ethyl (ethoxymethylene)cyanoacetate and ethoxymethylene malononitrile with phenylhydrazine. These pyrazoles were converted to pyrazolo[3,4-d]thiopyrimidines upon treatment with arylisothiocyanate and thiourea under microwave irradiation.

引用

页码：591 / 599

页数：9

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