Role of Calpain-10 in the Development of Diabetes Mellitus and Its Complications

被引：28
|
作者：
Panico, Pablo [1 ]
Maria Salazar, Ana [1 ]
Burns, Anna L. [1 ]
Ostrosky-Wegman, Patricia [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Genom Med & Environm Toxicol, Mexico City 04510, DF, Mexico
来源：
ARCHIVES OF MEDICAL RESEARCH | 2014年 / 45卷 / 02期
关键词：
Diabetes; Obesity; Calpain-10; CAPN10; polymorphisms; POLYCYSTIC-OVARY-SYNDROME; STIMULATED GLUCOSE-UPTAKE; HUMAN SKELETAL-MUSCLE; GENE POLYMORPHISMS; CAPN10; GENE; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; ATHEROSCLEROSIS RISK; PANCREATIC-ISLETS; 111/121; DIPLOTYPE;
D O I：
10.1016/j.arcmed.2014.01.005
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Calpain activity has been implicated in several cellular processes such as cell signaling, apoptosis, exocytosis, mitochondrial metabolism and cytoskeletal remodeling. Evidence has indicated that the impairment of calpain expression and the activity of different calpain family members are involved in diverse pathologies. Calpain-10 has been implicated in the development of type 2 diabetes, and polymorphisms in the CAPN10 gene have been associated with an increased risk of developing this disease. The present work focused on the molecular biology of calpain-10, supporting its key participation in glucose metabolism. Current knowledge regarding the role of calpain-10 in the development of type 2 diabetes mellitus and diabetes-related diseases is additionally reviewed. (C) 2014 IMSS. Published by Elsevier Inc.
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页码：103 / 115
页数：13
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