Design and synthesis of water-soluble bioconjugatable trans-AB-porphyrins

被引：30

作者：

Muresan, Ana Z. ^{[1
]}

Lindsey, Jonathan S. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 50期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Porphyrin; Water; Hydrocarbon; Water-soluble; Facial encumbrance; Bioconjugation;

D O I：

10.1016/j.tet.2008.08.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three free base porphyrins have been prepared that bear a polar and facially encumbering 2,4,6-tris(carboxymethoxy)phenyl Motif at One meso (5-) position. The only other substituent (15-position) comprises phenyl, formyl, or p-aminophenyl. The porphyrins exhibit solubility in water (or aqueous buffer Solutions) at pH >= 7 and concentrations >1 mM at room temperature. The concise syntheses, water solubility, and bioconjugatable handle make these porphyrin constructs Suitable for biological applications. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：11440 / 11448

页数：9

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