Isocoumarindole A, a Chlorinated Isocounnarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp.

被引：58

作者：

Chen, Minghua ^{[1
,2
,3
]}

Wang, Renzhong ^{[1
,2
,4
]}

Zhao, Wuli ^{[1
,2
]}

Yu, Liyan ^{[1
,2
]}

Zhang, Conghui ^{[1
,2
]}

Chang, Shanshan ^{[1
,2
]}

Li, Yan ^{[1
,2
]}

Zhang, Tao ^{[1
,2
]}

Xing, Jianguo ^{[3
]}

Gan, Maoluo ^{[1
,2
]}

Feng, Feng ^{[4
]}

Si, Shuyi ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, NHC Key Lab Microbial Drug Bioengn, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Inst Mat Med Xinjiang Uygur Autonomous Reg, Key Lab Uighur Med, Urumqi 830004, Peoples R China

[4] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DERIVATIVES; DIVERSITY; LICHEN; ACIDS;

D O I：

10.1021/acs.orglett.9b00385

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isocoumarindole A (1), a novel polyketide synthetase-nonribosomal peptide synthetase (PKS-NRPS) hybrid metabolite, was isolated from the endolichenic fungus Aspergillus sp. CPCC 400810. The structure of isocoumar-indole A (1) was featured by an unprecedented skeleton containing chlorinated isocoumarin and indole diketopiperazine alkaloid moieties linked by a carbon carbon bond, which was determined by a combination of spectroscopic analyses, Marfey's method, and calculations of NMR chemical shifts, ECD spectra, and optical rotation values. Isocoumarindole A showed significant cytotoxicity and mild antifungal activities.

引用

页码：1530 / 1533

页数：4

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