Intimal thickening under shear in a carotid bifurcation - A numerical study

被引:20
|
作者
Lee, D [1 ]
Chiu, JJ [1 ]
机构
[1] ACAD SINICA,INST BIOMED SCI,TAIPEI,TAIWAN
关键词
intimal thickening; arterial bifurcation flows; wall shear rate; hemodynamics; finite volume method; DOPPLER ANEMOMETER MEASUREMENTS; WALL SHEAR; 3-DIMENSIONAL MODEL; ARTERY BIFURCATION; PULSATILE FLOW; STEADY FLOW; STRESS; ATHEROSCLEROSIS; LOCALIZATION; COMPUTATION;
D O I
10.1016/0021-9290(95)00024-0
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
In the present study, a model for intimal thickening proposed by Friedman and his co-workers is employed to simulate the growth of intima in a carotid bifurcation with a steady how. The computer code developed is a pressure-based, finite volume method in a boundary-fitted coordinate system. A model bifurcation is used to demonstrate the usefulness of the numerical tool. The predicted results are consistent with the available experimental observations. The localization of plaques is shown. It is found that thicker intima is formed in preferential regions near the junction and the carotid bulb due to relatively low wall shear stresses. The intimal thickening tends to reduce the size of low shear regions. It is also found that the new geometry resulting from the thickening yields a more even stress distribution over the bifurcation. The effect of the branching ratio on the distribution of intimal thickening is also studied. The computer code provides a potential tool for visualization of intimal thickening.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 50 条
  • [21] PLATELET DEPOSITION FOLLOWING CAROTID ENDARTERECTOMY RELATES TO SUBSEQUENT INTIMAL THICKENING
    MEEK, AC
    CHIDLOW, A
    MCCOLLUM, CN
    GREENHALGH, RM
    BRITISH JOURNAL OF SURGERY, 1988, 75 (04) : 392 - 392
  • [22] Carotid artery ligation induced intimal thickening and proliferation is unaffected by ageing
    Brown, B. A.
    Williams, H.
    Bond, A. R.
    Angelini, G. D.
    Johnson, J. L.
    George, S. J.
    JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2018, 12 (03) : 529 - 537
  • [23] Carotid artery ligation induced intimal thickening and proliferation is unaffected by ageing
    B. A. Brown
    H. Williams
    A. R. Bond
    G. D. Angelini
    J. L. Johnson
    S. J. George
    Journal of Cell Communication and Signaling, 2018, 12 : 529 - 537
  • [24] Carotid Bifurcation Geometry Is an Independent Predictor of Early Wall Thickening at the Carotid Bulb
    Bijari, Payam B.
    Wasserman, Bruce A.
    Steinman, David A.
    STROKE, 2014, 45 (02) : 473 - 478
  • [25] LACIDIPINE - IN-VIVO EFFECTS ON INTIMAL CAROTID THICKENING IN HYPERCHOLESTEROLEMIC RABBITS
    SOMA, MR
    PAROLINI, C
    DONETTI, E
    GALLI, C
    PAOLETTI, R
    FUMAGALLI, R
    BRITISH JOURNAL OF PHARMACOLOGY, 1994, 111 : P21 - P21
  • [26] Numerical study on the influence of a symmetrical stenosis at the carotid sinus on the flow in the carotid bifurcation
    Biomechanical Engineering Laboratory, Sichuan University, Chengdu 610065, China
    不详
    Lixue Xuebao, 2006, 2 (270-275):
  • [27] Study on the shear thickening mechanism of multifunctional shear thickening gel and its energy dissipation under impact load
    Liu, Bing
    Du, Chengbin
    Deng, Huaxia
    Fu, Yankai
    Guo, Fei
    Song, Ling
    Gong, Xinglong
    POLYMER, 2022, 247
  • [28] Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study
    Devasia, Anup J.
    Joy, Binu
    Tarey, Subhash D.
    ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2016, 19 (01) : 48 - 51
  • [29] Numerical simulation of the flow in the carotid bifurcation
    Jou, LD
    Berger, SA
    THEORETICAL AND COMPUTATIONAL FLUID DYNAMICS, 1998, 10 (1-4) : 239 - 248
  • [30] Numerical Simulation of the Flow in the Carotid Bifurcation
    L.-D. Jou
    S.A. Berger
    Theoretical and Computational Fluid Dynamics, 1998, 10 : 239 - 248