Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

被引：0
|
作者：
Scholler, Jules [1 ]
Groux, Kassandra [1 ]
Goureau, Olivier [2 ]
Sahel, Jose-Alain [2 ,3 ,4 ,5 ]
Fink, Mathias [1 ]
Reichman, Sacha [2 ]
Boccara, Claude [1 ]
Grieve, Kate [2 ,3 ]
机构：
[1] PSL Univ, ESPCI Paris, Inst Langevin, CNRS, 10 Rue Vauquelin, Paris, France
[2] Sorbonne Univ, INSERM, CNRS, Inst Vis, F-75012 Paris, France
[3] Quinze Vingts Natl Eye Hosp, 28 Rue Charenton, F-75012 Paris, France
[4] Fdn Ophtalmol Rothschild, F-75019 Paris, France
[5] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15213 USA
来源：
LIGHT-SCIENCE & APPLICATIONS | 2020年 / 9卷 / 01期
基金：
欧洲研究理事会;
关键词：
HUMAN IPS CELLS; GENERATION; HISTORY; DISEASE;
D O I：
10.1038/s41377-020-00375-8
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Optical coherence tomography offers astounding opportunities to image the complex structure of living tissue but lacks functional information. We present dynamic full-field optical coherence tomography as a technique to noninvasively image living human induced pluripotent stem cell-derived retinal organoids. Coloured images with an endogenous contrast linked to organelle motility are generated, with submicrometre spatial resolution and millisecond temporal resolution, creating a way to identify specific cell types in living tissue via their function.
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收藏
页数：9
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