An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis

被引：80

作者：

Williamson, Deborah A. ^{[1
]}

Basu, Indira ^{[1
]}

Bower, James ^{[1
]}

Freeman, Joshua T. ^{[1
]}

Henderson, Gillian ^{[1
]}

Roberts, Sally A. ^{[1
]}

机构：

[1] Auckland Dist Hlth Board, Dept Clin Microbiol, Auckland, New Zealand

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2012年 / 74卷 / 02期

关键词：

Mycobacterium tuberculosis; Resistance; Rifampicin; Xpert MTB/RIF assay; SILENT MUTATION;

D O I：

10.1016/j.diagmicrobio.2012.06.013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：207 / 209

页数：3

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