Immunotherapy for the Management of Advanced Melanoma: The Next Steps

被引：12
|
作者：
Zikich, Dragoslav [1 ]
Schachter, Jacob [1 ]
Besser, Michal J. [1 ,2 ]
机构：
[1] Chaim Sheba Med Ctr, Ella Inst Melanoma, IL-52621 Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Dept Clin Microbiol & Immunol, IL-69978 Tel Aviv, Israel
来源：
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2013年 / 14卷 / 04期
关键词：
TUMOR-INFILTRATING LYMPHOCYTES; ADOPTIVE CELL TRANSFER; METASTATIC MELANOMA; T-CELLS; INTERLEUKIN-2; THERAPY; MALIGNANT-MELANOMA; ANTITUMOR IMMUNITY; CANCER REGRESSION; REGULATORY T; NK CELLS;
D O I：
10.1007/s40257-013-0013-0
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Melanoma is an immunogenic tumor that can induce a natural immune response. A number of immunotherapy-based approaches have been developed over the past decades, and certain degrees of effectiveness were achieved by the use of cytokines, adoptive cell transfer and T-cell immune modulators. Currently, interleukin-2 and the immune stimulatory antibody, ipilimumab, are the only two approved immunotherapies for metastatic melanoma, but various new therapies are in promising developmental stages. This comprehensive review will discuss the latest achievements of immunotherapy and emerging directions for the management of advanced melanoma.
引用
收藏
页码：261 / 272
页数：12
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