Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats

被引：6
|
作者：
Hidaka, Noriaki [1 ]
Suemaru, Katsuya [1 ]
Kato, Yoshihisa [2 ]
Araki, Hiroaki [1 ]
机构：
[1] Ehime Univ Hosp, Div Pharm, Toon, Ehime 7910295, Japan
[2] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Dept Pharmacokinet & Pharmacodynam, Sanuki, Kagawa 7692193, Japan
来源：
EPILEPSY RESEARCH | 2013年 / 104卷 / 1-2期
关键词：
Electroconvulsive seizure; Spontaneous alternation behavior; Physostigmine; Anabasine; ABT-418; SPONTANEOUS-ALTERNATION BEHAVIOR; AGONIST; BRAIN; ATTENUATION; ANTAGONIST; DEFICITS; EPILEPSY; MAZE;
D O I：
10.1016/j.eplepsyres.2012.09.017
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The alpha 4 beta 2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the alpha 7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated ECS caused a reduction of alpha 4 nAChR-positive cells in the prefrontal cortex and hippocampus. Thus, the alpha 4 beta 2 nAChR is related to ECS-induced deficits in rats. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.
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页码：181 / 185
页数：5
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