Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream

被引：1312

作者：

Arkin, MR ^{[1
]}

Wells, JA ^{[1
]}

机构：

[1] Sunesis Pharmaceut, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrd1343

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Protein-protein interactions have a key role in most biological processes, and offer attractive opportunities for therapeutic intervention. Developing small molecules that modulate protein-protein interactions is difficult, owing to issues such as the lack of well-defined binding pockets. Nevertheless, there has been important progress in this endeavour in recent years. Here, we use illustrative examples to discuss general strategies for addressing the challenges inherent in the discovery and characterization of small-molecule inhibitors of protein-protein interactions.

引用

页码：301 / 317

页数：17

共 50 条

[31] Screening of Small-Molecule Inhibitors of Protein-Protein Interaction with Capillary Electrophoresis Frontal Analysis
Xu, Mei
Liu, Chao
Zhou, Mi
Li, Qing
Wang, Renxiao
Kang, Jingwu
ANALYTICAL CHEMISTRY, 2016, 88 (16) : 8050 - 8057
[32] Small-Molecule Inhibitors of the NusB-NusE Protein-Protein Interaction with Antibiotic Activity
Cossar, Peter J.
Abdel-Hamid, Mohammed K.
Ma, Cong
Sakoff, Jennette A.
Trinh, Trieu N.
Gordon, Christopher P.
Lewis, Peter J.
McCluskey, Adam
ACS OMEGA, 2017, 2 (07): : 3839 - 3857
[33] AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors
Koes, David R.
Domling, Alexander
Camacho, Carlos J.
PROTEIN SCIENCE, 2018, 27 (01) : 229 - 232
[34] Identification of small-molecule protein-protein interaction inhibitors for NKG2D
Thompson, Aaron A.
Harbut, Michael B.
Kung, Pei-Pei
Karpowich, Nathan K.
Branson, Jeffrey D.
Grant, Joanna C.
Hagan, Deborah
Pascual, Heather A.
Bai, Guoyun
Zavareh, Reza Beheshti
Coate, Heather R.
Collins, Bernard C.
Cote, Marjorie
Gelin, Christine F.
Damm-Ganamet, Kelly L.
Gholami, Hadi
Huff, Adam R.
Limon, Luis
Lum, Kevin J.
Mak, Puiying A.
Nakafuku, Kohki M.
V. Price, Edmund
Shih, Amy Y.
Tootoonchi, Mandana
Vellore, Nadeem A.
Wang, Jocelyn
Wei, Na
Ziff, Jeannie
Berger, Scott B.
Edwards, James P.
Gardet, Agnes
Sun, Siquan
Towne, Jennifer E.
Venable, Jennifer D.
Shi, Zhicai
Venkatesan, Hariharan
Rives, Marie-Laure
Sharma, Sujata
Shireman, Brock T.
Allen, Samantha J.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (18)
[35] Magnetic "Fishing" Assay To Screen Small-Molecule Mixtures for Modulators of Protein-Protein Interactions
McFadden, Meghan J.
Junop, Murray S.
Brennan, John D.
ANALYTICAL CHEMISTRY, 2010, 82 (23) : 9850 - 9857
[36] Development of small molecule inhibitors that target protein-protein interactions in a transcription factor
Prive, Gilbert
Kuntz, Douglas
Poda, Gennady
Isaac, Methvin
Al-awar, Rima
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2018, 74 : A405 - A405
[37] Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein-protein interactions
Moon, Heejo
Lim, Hyun-Suk
CURRENT OPINION IN CHEMICAL BIOLOGY, 2015, 24 : 38 - 47
[38] Progress in discovery of small-molecule modulators of protein-protein interactions via fragment screening
Magee, Thomas V.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (12) : 2461 - 2468
[39] Rational Design of Small-Molecule Inhibitors for β-Catenin/T-Cell Factor Protein-Protein Interactions by Bioisostere Replacement
Yu, Binxun
Huang, Zheng
Zhang, Min
Dillard, Darren R.
Ji, Haitao
ACS CHEMICAL BIOLOGY, 2013, 8 (03) : 524 - 529
[40] Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interactions
Hoggard, Logan R.
Zhang, Yongqiang
Zhang, Min
Panic, Vanja
Wisniewski, John A.
Ji, Haitao
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (38) : 12249 - 12260

← 1 2 3 4 5 →