Posttraining lesions of the auditory thalamus, but not cortex, disrupt the inhibition of fear conditioned to an auditory stimulus

被引:9
|
作者
Heldt, SA
Falls, WA
机构
[1] No Illinois Univ, Dept Psychol, De Kalb, IL 60115 USA
[2] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA
关键词
anxiety; conditioned inhibition; fear-potentiated startle;
D O I
10.1111/j.1460-9568.2006.04604.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of this study was to examine the effects of lesions within the auditory system in an effort to disrupt the processing of the noise stimulus conditioned to inhibit fear. To accomplish this, three experiments were conducted in which rats were first given feature-negative discrimination training in which a noise was conditioned to inhibit fear to a light that signals danger. Following training, rats were given lesions of the medial geniculate body (MGB), auditory thalamus (ADT), or auditory cortex (CTX). Next, rats were tested for the ability to inhibit fear in the presence of the noise safety signal. The results of these experiments indicated that bilateral lesions of ADT disrupted the ability of the noise inhibitor to inhibit fear. In contrast, lesions largely restricted to the MGB or CTX did not disrupt the inhibition of fear. Along with past studies, these results suggest that an auditory pathway(s), which includes projections from the tectum to the ADT, is used to detect the safety properties previously conditioned to an auditory stimulus.
引用
收藏
页码:765 / 779
页数:15
相关论文
共 50 条
  • [21] DESCENDING CONNECTIONS OF AUDITORY CORTEX AND THALAMUS OF THE CAT
    WALTHER, JB
    RASMUSSEN, GL
    [J]. FEDERATION PROCEEDINGS, 1960, 19 (01) : 291 - 291
  • [22] On the classification of pathways in the auditory midbrain, thalamus, and cortex
    Lee, Charles C.
    Sherman, Murray
    [J]. HEARING RESEARCH, 2011, 276 (1-2) : 79 - 87
  • [23] Contribution of Inhibition to Stimulus Selectivity in Primary Auditory Cortex of Awake Primates
    Sadagopan, Srivatsun
    Wang, Xiaoqin
    [J]. JOURNAL OF NEUROSCIENCE, 2010, 30 (21): : 7314 - 7325
  • [24] Connections of functional areas in the mustached bat's auditory cortex with the auditory thalamus
    Pearson, James M.
    Crocker, William D.
    Fitzpatrick, Douglas C.
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 500 (02) : 401 - 418
  • [25] Hemispheric asymmetry for auditory processing in the human auditory brain stem, thalamus, and cortex
    Schoenwiesner, Marc
    Krumbholz, Katrin
    Ruebsamen, Rudolf
    Fink, Gereon R.
    von Cramon, D. Yves
    [J]. CEREBRAL CORTEX, 2007, 17 (02) : 492 - 499
  • [26] An Overview of Stimulus-Specific Adaptation in the Auditory Thalamus
    Flora M. Antunes
    Manuel S. Malmierca
    [J]. Brain Topography, 2014, 27 : 480 - 499
  • [27] Stimulus-Specific Adaptation Occurs in the Auditory Thalamus
    Anderson, Lucy A.
    Christianson, G. Bjoern
    Linden, Jennifer F.
    [J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (22): : 7359 - 7363
  • [28] An Overview of Stimulus-Specific Adaptation in the Auditory Thalamus
    Antunes, Flora M.
    Malmierca, Manuel S.
    [J]. BRAIN TOPOGRAPHY, 2014, 27 (04) : 480 - 499
  • [29] Inhibition in the Human Auditory Cortex
    Inui, Koji
    Nakagawa, Kei
    Nishihara, Makoto
    Motomura, Eishi
    Kakigi, Ryusuke
    [J]. PLOS ONE, 2016, 11 (05):
  • [30] Comparison of auditory deficits associated with neglect and auditory cortex lesions
    Gutschalk, Alexander
    Brandt, Tobias
    Bartsch, Andreas
    Jansen, Claudia
    [J]. NEUROPSYCHOLOGIA, 2012, 50 (05) : 926 - 938