Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice

被引：101
|
作者：
Usherwood, EJ
Stewart, JP
Nash, AA
机构：
来源：
JOURNAL OF VIROLOGY | 1996年 / 70卷 / 09期
关键词：
D O I：
10.1128/JVI.70.9.6516-6518.1996
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.
引用
收藏
页码：6516 / 6518
页数：3
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