Cis-regulatory logic in archaeal transcription

被引:36
|
作者
Peeters, Eveline [1 ]
Peixeiro, Nuno [2 ]
Sezonov, Guennadi [3 ,4 ]
机构
[1] Vrije Univ Brussel, Microbiol Res Grp, B-1050 Brussels, Belgium
[2] Commissariat Energie Atom & Energies Alternat CEA, IBiTec S, Serv Biol Integrat & Genet Mol, F-91191 Gif Sur Yvette, France
[3] Inst Pasteur, Unite Biol Mol Gene Extremophiles, F-75724 Paris 15, France
[4] Univ Paris 06, UMR Systemat Adaptat Evolut 7138, Paris, France
关键词
activation; Archaea; DNA binding; operator; repression; transcription regulation; SULFOLOBUS-SOLFATARICUS; SS-LRPB; METHANOCOCCUS-MARIPALUDIS; PROMOTER ARCHITECTURE; DNA; EXPRESSION; OPERON; SPECIFICITY; PROTEIN; IDENTIFICATION;
D O I
10.1042/BST20120312
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
For cellular fitness and survival, gene expression levels need to be regulated in response to a wealth of cellular and environmental signals. TFs (transcription factors) execute a large part of this regulation by interacting with the basal transcription machinery at promoter regions. Archaea are characterized by a simplified eukaryote-like basal transcription machinery and bacteria-type TFs, which convert sequence information into a gene expression output according to cis-regulatory rules. In the present review, we discuss the current state of knowledge about these rules in archaeal systems, ranging from DNA-binding specificities and operator architecture to regulatory mechanisms.
引用
收藏
页码:326 / 331
页数:6
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