Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis

被引：100
|
作者：
Breivik, J [1 ]
Gaudernack, G [1 ]
机构：
[1] Norwegian Radium Hosp, Sect Immunotherapy, N-0310 Oslo, Norway
来源：
SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 04期
关键词：
neoplastic transformation; evolutionary mechanisms; tumor progression;
D O I：
10.1006/scbi.1999.0123
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neoplastic transformation is increasingly understood in terms of evolutionary mechanisms, and it is now widely accepted that tumor progression involves natural selection of genetic variants occurring in the somatic environment. Here we give a review of data that substantiate this Darwinian view to tumorigenesis, with particular emphasis on recent advances related to colorectal cancer. We specifically focus on the controversies related to genomic instability and DNA methylation, and present a model, which interrelates these phenomena to the basic evolutionary concept of biology.
引用
收藏
页码：245 / 254
页数：10
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