The ESCRT machinery: new functions in viral and cellular biology

被引：59
|
作者：
Carlton, Jeremy G. [1 ]
Martin-Serrano, Juan [1 ]
机构：
[1] Guys Hosp, Univ London Kings Coll, Sch Med, Dept Infect Dis, London SE1 9RT, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷
基金：
英国医学研究理事会;
关键词：
endosomal sorting complex required for transport (ESCRT); multivesicular body (MVB); retrovirus; tumour susceptibility gene 101 (Tsg101); vacuolar protein sorting 4 (Vps4); virus; IMMUNODEFICIENCY-VIRUS TYPE-1; PROTEIN-SORTING PATHWAY; LATE-BUDDING DOMAINS; ROUS-SARCOMA-VIRUS; YPXL LATE DOMAINS; PARTICLE RELEASE; STRUCTURAL BASIS; HIV-1; P6; UBIQUITIN; CYTOKINESIS;
D O I：
10.1042/BST0370195
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ESCRT (endosomal sorting complex required for transport) machinery consists of a number of cytosolic proteins that make up three functional subcomplexes: ESCRT-I, ESCRT-II and ESCRT-III. These proteins function in multivesicular body formation and cell division and are co-opted by enveloped retroviruses to facilitate viral egress. Analysis of these functions may help illuminate conserved mechanisms of ESCRT function.
引用
收藏
页码：195 / 199
页数：5
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