Copper-catalyzed intramolecular dehydrogenative cyclization: direct access to sensitive formyl-substituted imidazo[1,2-a]pyridines

被引：7
|
作者：
Zhai, Li-Hai [1 ,2 ]
Guo, Li-Hong [2 ]
Sun, Bai-Wang [1 ]
机构：
[1] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China
[2] Lunan Pharmaceut Co Ltd, Linyi 276000, Shandong, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 113期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; C-H; OXIDATIVE ANNULATION; BOND ACTIVATION; 2-AMINOPYRIDINES; AIR; AMINOPYRIDINES; NITROOLEFINS; ZOLPIDEM; PYRROLES;
D O I：
10.1039/c5ra19085a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A direct method for the synthesis of formyl-substituted imidazo[1,2-a]pyridines was achieved easily from cyclization of aminopyridines and cinnamaldehydes via copper catalysis. This oxidative cyclization process involved direct C-H bond functionalization, and C-C/C-N bond formation. In this transformation, the sensitive aldehyde group was preserved under oxidative conditions.
引用
收藏
页码：93631 / 93634
页数：4
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