Telomeres: has cancer's Achilles' heel been exposed?

被引：14

作者：

Zumstein, LA ^{[1
]}

Lundblad, V

机构：

[1] Introgen Therapeut Inc, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 10期

关键词：

D O I：

10.1038/13451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase allows cells to grow indefinitely, and is expressed in the majority of human cancers. New data suggest, however, that telomere maintenance might be a stumbling block on the path to immortalization and that inhibition of telomere replication can attenuate human cancer cell growth (pages 1164–1170) .

引用

页码：1129 / 1130

页数：2

共 50 条

[21] An Achilles heel for kidney cancer
[J]. Nature, 2017, 547 (7664) : 383 - 383
[22] An Achilles' heel for breast cancer?
Keith W Caldecott
Anthony Chalmers
[J]. Nature Structural & Molecular Biology, 2005, 12 : 387 - 388
[23] Philippa Foot's virtue ethics has an Achilles' heel ('Natural Goodness')
Woodcock, Scott
[J]. DIALOGUE-CANADIAN PHILOSOPHICAL REVIEW, 2006, 45 (03) : 445 - 468
[24] Feynman's Achilles' Heel?
Gordon, Lyndsay G. M.
[J]. SECOND LAW OF THERMODYNAMICS: STATUS AND CHALLENGES, 2011, 1411
[25] HiV's ACHILLES' HEEL
Sanders, Rogier W.
Wilson, Ian A.
Moore, John P.
[J]. SCIENTIFIC AMERICAN, 2016, 315 (06) : 50 - 55
[26] Ebola's Achilles' heel
Everts, Sarah
[J]. CHEMICAL & ENGINEERING NEWS, 2016, 94 (27) : 9 - 9
[27] HIV's Achilles' heel
Beardsley, T
[J]. SCIENTIFIC AMERICAN, 1996, 275 (03) : 16 - &
[28] Allergy's Achilles' heel?
Brian J Sutton
[J]. Nature Chemical Biology, 2013, 9 : 757 - 759
[29] An/sb's Achilles' heel
邓艳军
[J]. 第二课堂(A), 2015, (03) : 13 - 13
[30] Men's Achilles' heel: prostate cancer and the reconstruction of masculinity
Andreasson, Jesper
Johansson, Thomas
Danemalm-Jaegervall, Carina
[J]. CULTURE HEALTH & SEXUALITY, 2023, 25 (12) : 1675 - 1689

← 1 2 3 4 5 →