Vinculin, cell mechanics and tumour cell invasion

被引：73
|
作者：
Goldmann, Wolfgang H. [1 ]
Auernheimer, Vera [1 ]
Thievessen, Ingo [1 ]
Fabry, Ben [1 ]
机构：
[1] Univ Erlangen Nurnberg, Ctr Med Phys & Technol, Biophys Grp, D-91052 Erlangen, Germany
来源：
CELL BIOLOGY INTERNATIONAL | 2013年 / 37卷 / 05期
关键词：
vinculin; focal adhesions; adherence junctions; cancer; cell mechanics; ECM; 2D and 3D environment; FOCAL ADHESION FORMATION; CARCINOMA-CELLS; ALPHA-ACTININ; INTRAMOLECULAR ASSOCIATION; TYROSINE PHOSPHORYLATION; PROTEIN VINCULIN; MATRIX ADHESION; BINDING-SITES; F9; CELLS; TALIN;
D O I：
10.1002/cbin.10064
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.
引用
收藏
页码：397 / 405
页数：9
相关论文
共 50 条
  • [31] Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase plasminogen activator receptor
    Albo, D
    Rothman, VL
    Roberts, DD
    Tuszynski, GP
    BRITISH JOURNAL OF CANCER, 2000, 83 (03) : 298 - 306
  • [32] Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase plasminogen activator receptor
    D Albo
    V L Rothman
    D D Roberts
    G P Tuszynski
    British Journal of Cancer, 2000, 83 : 298 - 306
  • [33] Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer
    Ruiz, C.
    Holz, D.
    Oeggerli, M.
    Schneider, S.
    Kiefer, J.
    Gonzales, I.
    Zellweger, T.
    Barrett, M.
    Azorsa, D.
    Bubendorf, L.
    EJC SUPPLEMENTS, 2010, 8 (05): : 13 - 13
  • [34] Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
    Bircan Coban
    Cecilia Bergonzini
    Annelien J. M. Zweemer
    Erik H. J. Danen
    British Journal of Cancer, 2021, 124 : 49 - 57
  • [35] Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
    Coban, Bircan
    Bergonzini, Cecilia
    Zweemer, Annelien J. M.
    Danen, Erik H. J.
    BRITISH JOURNAL OF CANCER, 2021, 124 (01) : 49 - 57
  • [36] Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters
    Entschladen, F
    Drell, TL
    Lang, K
    Joseph, J
    Zaenker, KS
    LANCET ONCOLOGY, 2004, 5 (04): : 254 - 258
  • [37] Unjamming tumour cell invasion through cGAS-STING
    Deyell, Matthew
    Bakhoum, Samuel F.
    NATURE MATERIALS, 2023, 22 (05) : 532 - 533
  • [38] The composition of mammary gland stroma regulates tumour cell invasion
    Gomm J.
    Breast Cancer Research, 2 (1)
  • [39] Tumour-cell invasion and migration: Diversity and escape mechanisms
    Friedl, P
    Wolf, K
    NATURE REVIEWS CANCER, 2003, 3 (05) : 362 - 374
  • [40] Tumour-cell invasion and migration: diversity and escape mechanisms
    Peter Friedl
    Katarina Wolf
    Nature Reviews Cancer, 2003, 3 : 362 - 374
12345