Vinculin, cell mechanics and tumour cell invasion

被引：73
|
作者：
Goldmann, Wolfgang H. [1 ]
Auernheimer, Vera [1 ]
Thievessen, Ingo [1 ]
Fabry, Ben [1 ]
机构：
[1] Univ Erlangen Nurnberg, Ctr Med Phys & Technol, Biophys Grp, D-91052 Erlangen, Germany
来源：
CELL BIOLOGY INTERNATIONAL | 2013年 / 37卷 / 05期
关键词：
vinculin; focal adhesions; adherence junctions; cancer; cell mechanics; ECM; 2D and 3D environment; FOCAL ADHESION FORMATION; CARCINOMA-CELLS; ALPHA-ACTININ; INTRAMOLECULAR ASSOCIATION; TYROSINE PHOSPHORYLATION; PROTEIN VINCULIN; MATRIX ADHESION; BINDING-SITES; F9; CELLS; TALIN;
D O I：
10.1002/cbin.10064
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.
引用
收藏
页码：397 / 405
页数：9
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