STEREOSELECTIVE SYNTHESIS OF β-AMINO ACIDS BY ALDOL-TYPE ADDITION

被引：0

作者：

Benito-Garagorri, David ^{[1
]}

Felzmann, Wolfgang ^{[1
]}

Nerdinger, Sven ^{[1
]}

Hoferl-Prantz, Kathrin ^{[1
]}

机构：

[1] Sandoz GmbH, Biochem Str 10, A-6250 Kundl, Austria

来源：

HETEROCYCLES | 2020年 / 101卷 / 01期

关键词：

Asymmetric Synthesis; Mukaiyama-Type Aldol Addition; HCV Drug Telaprevir; beta-Amino Acid; ASYMMETRIC-SYNTHESIS; TAXOL;

D O I：

10.3987/COM-19-S(F)4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of alpha-oxygenated beta-amino acid derivatives using an aldol-type addition is described. Depending on the enol equivalent different oxidation states of the oxygen substituent are accessible, while choosing a chiral imine allows to generate the aldol product in a stereoselective manner. This methodology has been applied to the synthesis of the biologically active compound Telaprevir, used in the traetment of hepatitis C.

引用

页码：299 / 311

页数：13

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