Catechol-O-Methyltransferase Genetic Variant Associated with the Risk of Alzheimer's Disease in a Brazilian Population

被引：7
|
作者：
Pereira, Patricia Araujo [1 ]
Romano-Silva, Marco Aurelio [1 ]
Camargos Bicalho, Maria Aparecida [2 ]
de Moraes, Edgar Nunes [1 ,2 ]
Malloy-Diniz, Leandro [1 ,2 ]
Garcia Santos Pimenta, Guilherme Jose [1 ]
Mello, Marina Pena [1 ]
Reis Sguizzato Bozzi, Isadora Cristine [1 ]
de Marco, Luiz Armando [1 ]
Nicolato, Rodrigo [1 ]
Miranda, Debora Marques [1 ]
机构：
[1] Univ Fed Minas Gerais, Fac Med, INCT Med Mol, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Hosp Clin, Ctr Jenny Faria Assistencia Saude Idoso & Mulher, BR-30130100 Belo Horizonte, MG, Brazil
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 34卷 / 02期
关键词：
Catechol-O-methyltransferase; Single-nucleotide polymorphism; Alzheimer's disease; Behavioral and psychological symptoms of dementia; POLYMORPHISM; PSYCHOSIS; COMT; DEMENTIA; SYMPTOMS; SCHIZOPHRENIA; AGGRESSION; PREDICTORS; HAPLOTYPES; PHENOTYPE;
D O I：
10.1159/000341578
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The aim of the present study was to examine the association between polymorphism in the catechol-O-methyltransferase (COMT) gene and Alzheimer's disease (AD) in a Brazilian population. The case-control method was used to study the association between AD and genetic variants of COMT. Six tag single-nucleotide polymorphisms (SNPs) in the COMT gene were genotyped by RT-PCR. Our findings showed that the 6 tag SNPs analyzed in this study were not associated with AD at the allele and genotype levels in comparison with the control group. No statistical difference was found between groups with and without behavioral and psychological symptoms of dementia (BPSD). Our results do not support the hypothesis that the polymorphisms of the COMT gene may be associated with susceptibility to AD with and without BPSD. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：90 / 95
页数：6
相关论文
共 50 条
  • [41] BLOOD CATECHOL-O-METHYLTRANSFERASE ACTIVITY IN PARKINSONS DISEASE
    FRERE, JM
    BARBEAU, A
    [J]. LANCET, 1971, 2 (7718): : 269 - &
  • [42] Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic -: Pharmacodynarnic pattern in patients with Parkinson's disease
    Contin, M
    Martinelli, P
    Mochi, M
    Riva, R
    Albani, F
    Baruzzi, A
    [J]. MOVEMENT DISORDERS, 2005, 20 (06) : 734 - 739
  • [43] Association between Catechol-O-Methyltransferase Gene Variant and Bipolar Disorder
    Kutumbarao, N. H. V.
    Das, Arundhuti
    Lakshmi, V.
    [J]. INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2011, 11 (01) : 55 - 58
  • [44] Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease
    Patel, Chirag N.
    Georrge, John J.
    Modi, Krunal M.
    Narechania, Moksha B.
    Patel, Daxesh P.
    Gonzalez, Frank J.
    Pandya, Himanshu A.
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2018, 36 (15): : 3938 - 3957
  • [45] Catechol-O-methyltransferase Val158Met polymorphism on structural covariance networks in Alzheimer's disease
    Chang, C. C.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 321 - 321
  • [46] Catechol-O-methyltransferase (COMT) genetic polymorphisms, smoking and breast cancer risk.
    Ambrosone, CB
    Thompson, PA
    Shields, PG
    Freudenheim, JL
    Stone, A
    Marshall, JR
    Graham, S
    Vena, JE
    Laughlin, R
    Nemoto, T
    Kadlubar, FF
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (11) : S65 - S65
  • [47] Impact of catechol-O-methyltransferase genetic polymorphisms and age on empathy
    Hsu, Jing-Hao
    Tan, Chun-Hsiang
    Yu, Rwei-Ling
    [J]. CURRENT PSYCHOLOGY, 2023, 42 (26) : 23059 - 23068
  • [48] Impact of catechol-O-methyltransferase genetic polymorphisms and age on empathy
    Jing-Hao Hsu
    Chun-Hsiang Tan
    Rwei-Ling Yu
    [J]. Current Psychology, 2023, 42 : 23059 - 23068
  • [49] Catechol-O-methyltransferase inhibitors: Clinical potential in the treatment of Parkinson's disease
    Dingemanse, J
    [J]. DRUG DEVELOPMENT RESEARCH, 1997, 42 (01) : 1 - 25
  • [50] Entacapone:: A catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease
    Najib, J
    [J]. CLINICAL THERAPEUTICS, 2001, 23 (06) : 802 - 832
12345