Catechol-O-Methyltransferase Genetic Variant Associated with the Risk of Alzheimer's Disease in a Brazilian Population

被引：7
|
作者：
Pereira, Patricia Araujo [1 ]
Romano-Silva, Marco Aurelio [1 ]
Camargos Bicalho, Maria Aparecida [2 ]
de Moraes, Edgar Nunes [1 ,2 ]
Malloy-Diniz, Leandro [1 ,2 ]
Garcia Santos Pimenta, Guilherme Jose [1 ]
Mello, Marina Pena [1 ]
Reis Sguizzato Bozzi, Isadora Cristine [1 ]
de Marco, Luiz Armando [1 ]
Nicolato, Rodrigo [1 ]
Miranda, Debora Marques [1 ]
机构：
[1] Univ Fed Minas Gerais, Fac Med, INCT Med Mol, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Hosp Clin, Ctr Jenny Faria Assistencia Saude Idoso & Mulher, BR-30130100 Belo Horizonte, MG, Brazil
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 34卷 / 02期
关键词：
Catechol-O-methyltransferase; Single-nucleotide polymorphism; Alzheimer's disease; Behavioral and psychological symptoms of dementia; POLYMORPHISM; PSYCHOSIS; COMT; DEMENTIA; SYMPTOMS; SCHIZOPHRENIA; AGGRESSION; PREDICTORS; HAPLOTYPES; PHENOTYPE;
D O I：
10.1159/000341578
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The aim of the present study was to examine the association between polymorphism in the catechol-O-methyltransferase (COMT) gene and Alzheimer's disease (AD) in a Brazilian population. The case-control method was used to study the association between AD and genetic variants of COMT. Six tag single-nucleotide polymorphisms (SNPs) in the COMT gene were genotyped by RT-PCR. Our findings showed that the 6 tag SNPs analyzed in this study were not associated with AD at the allele and genotype levels in comparison with the control group. No statistical difference was found between groups with and without behavioral and psychological symptoms of dementia (BPSD). Our results do not support the hypothesis that the polymorphisms of the COMT gene may be associated with susceptibility to AD with and without BPSD. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：90 / 95
页数：6
相关论文
共 50 条
  • [1] Catechol-O-methyltransferase, Cognition and Alzheimer's Disease
    Perkovic, Matea Nikolac
    Strac, Dubravka Svob
    Tudor, Lucija
    Konjevod, Marcela
    Erjavec, Gordana Nedic
    Pivac, Nela
    [J]. CURRENT ALZHEIMER RESEARCH, 2018, 15 (05) : 408 - 419
  • [2] Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease
    Borroni, B
    Agosti, C
    Archetti, S
    Costanzi, C
    Bonomi, S
    Ghianda, D
    Lenzi, GL
    Caimi, L
    Di Luca, M
    Padovani, A
    [J]. NEUROSCIENCE LETTERS, 2004, 370 (2-3) : 127 - 129
  • [3] Catechol-O-Methyltransferase and Alzheimer's Disease: A Review of Biological and Genetic Findings
    Serretti, Alessandro
    Olgiati, Paolo
    [J]. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2012, 11 (03) : 299 - 305
  • [4] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    B Devlin
    B G Pollock
    D L Sukonick
    K B Kastango
    S-A Bacanu
    K V Chowdari
    S T DeKosky
    R E Ferrell
    [J]. Molecular Psychiatry, 2005, 10 : 1026 - 1036
  • [5] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    Sweet, RA
    Devlin, B
    Pollock, BG
    Sukonick, DL
    Kastango, KB
    Bacanu, SA
    Chowdari, KV
    DeKosky, ST
    Ferrell, RE
    [J]. MOLECULAR PSYCHIATRY, 2005, 10 (11) : 1026 - 1036
  • [6] Catechol-O-methyltransferase and Parkinson's disease
    Tai, CH
    Wu, RM
    [J]. ACTA MEDICA OKAYAMA, 2002, 56 (01) : 1 - 6
  • [7] Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease
    Lin, Chin-Hsien
    Chaudhuri, K. Ray
    Fan, Jun-Yu
    Ko, Chia-I.
    Rizos, Alexandra
    Chang, Chia-Wen
    Lin, Han-I.
    Wu, Yih-Ru
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [8] Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
    Chin-Hsien Lin
    K. Ray Chaudhuri
    Jun-Yu Fan
    Chia-I. Ko
    Alexandra Rizos
    Chia-Wen Chang
    Han-I. Lin
    Yih-Ru Wu
    [J]. Scientific Reports, 7
  • [9] Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population
    Kocabas, NA
    Karakaya, AE
    Cholerton, S
    Sardas, S
    [J]. ARCHIVES OF TOXICOLOGY, 2001, 75 (07) : 407 - 409
  • [10] Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population
    Neslihan Kocabaş
    Ali Karakaya
    Suzanne Cholerton
    Şemra Şardaş
    [J]. Archives of Toxicology, 2001, 75 : 407 - 409
12345