Necrobiosis lipoidica - Clinical Findings and Therapeutic Approaches

Necrobiosis lipoidica is a rare granulomatous skin disorder presenting with yellowish-brown plaques preferentially on the lower extremities. The appearance of ulcerative lesions can complicate the course of the disease. Clear therapeutic recommendations are still missing since large randomized controlled trials are lacking due to small number of patients. Next to corticosteroids the use of fumaric acid esters and biologicals represent encouraging therapeutic approaches.