Optimisation of Process Algebra Models Using Evolutionary Computation

被引:0
|
作者
Marco, David [1 ]
Cairns, David [1 ]
Shankland, Carron [1 ]
机构
[1] Univ Stirling, Sch Nat Sci, Stirling FK9 4LA, Scotland
关键词
Process algebra; Emergent properties in complex biological systems; In-silico optimization of biological systems; POPULATION-DYNAMICS; SYSTEMS; BIOLOGY;
D O I
暂无
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We propose that process algebras and evolutionary algorithms have complementary strengths for developing models of complex systems. Evolutionary algorithms are powerful methods for finding solutions to optimisation problems with large search spaces but require an accurately defined fitness function to provide valid results. Process algebras are an effective method for defining models of complex interacting processes, but tuning parameters to allow model outputs to match experimental data can be difficult. Defining models in the first place can also be problematic. Our long term goal is to build a framework to synthesise process algebra models. Here we present a first step in that development: combining process algebra with an evolutionary approach to fine tune the numeric parameters of predefined models. The Evolving Process Algebra (EPA) framework is demonstrated through examples from epidemiology and computer science. Program track - Computational Intelligence in Bioinformatics and Computational Biology
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页码:1296 / 1301
页数:6
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