PRMT5 Inhibition Enhances Elimination of FLT3-ITD AML Stem Cells in Combination with TKI Treatment

被引:1
|
作者
Kumar, Harish [1 ]
Dhir, Aditi [2 ]
Paterson, Andrew J. [3 ]
Anderson, Nick R. [4 ]
Qiu, Shaowei [4 ]
Zhao, Xinyang [5 ]
Lu, Rui [4 ]
Bhatia, Ravi [4 ]
机构
[1] Univ Alabama Birmingham, Dept Med, UAB, Div Hematol & Oncol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Div Endocrinol Diabet & Metab, Birmingham, AL 35294 USA
[4] Univ Alabama Birmingham, Div Hematol & Oncol, Dept Med, Birmingham, AL 35294 USA
[5] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
关键词
D O I
10.1182/blood-2022-168326
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:3073 / 3074
页数:2
相关论文
共 50 条
  • [31] Treatment of FLT3-ITD Positive AML Relapsing After Allogeneic Hematopoietic Stem Cell Transplant (HSCT) with Sorafenib
    Sharma, Manish R.
    Ravandi, Farhad
    Chiattone, Alexandre
    Kebriaei, Partow
    Popat, Uday
    Giralt, Sergio
    Bashir, Qaiser
    Qazilbash, Muzaffar H.
    Nieto, Yago
    Yuen, Carrie Hai-Lai
    Parmar, Simrit
    Kantarjian, Hagop M.
    Cortes, Jorge
    Kadia, Tapan
    Borthakur, Gautam
    Champlin, Richard E.
    De Lima, Marcos
    BLOOD, 2010, 116 (21) : 1426 - 1426
  • [32] Proteasomal alterations in a newly created model of FLT3-ITD positive AML with acquired pan-TKI resistance
    Wilson, Katie
    Irwin, Mary E.
    Chandra, Joya
    CANCER RESEARCH, 2014, 74 (19)
  • [33] Characterization of genomic alterations of cytarabine-resistant AML cells with FLT3-ITD mutation
    Yen, J. H.
    Chen, Z. A.
    Lin, L. I.
    Chen, P. Y.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 1608 - 1608
  • [34] Molecular studies for gain of cytarabine-resistance in AML cells with FLT3-ITD mutations
    Chen, P.
    Chen, Z.
    Lin, L.
    Yen, J.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2020, 28 (SUPPL 1) : 487 - 488
  • [35] The benefit of treatment with quizartinib and subsequent bridging to HSCT for FLT3-ITD(+) patients with AML.
    Levis, Mark J.
    Martinelli, Giovanni
    Perl, Alexander E.
    Dombret, Herve
    Steffen, Bjoern
    Rousselot, Philippe H.
    Estey, Elihu
    Shah, Neil P.
    Gammon, Guy
    Trone, Denise
    Cortes, Jorge E.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [36] The effect of FLT3 gene expression in senescence and telomere length regulation in AML cells with FLT3-ITD mutation
    Hong, Jing Siou
    Yen, Jui Hung
    Wu, Chia Ling
    Chen, Pei Yi
    CANCER SCIENCE, 2025, 116 : 256 - 256
  • [37] The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells
    Hospital, Marie-Anne
    Green, Alexa S.
    Lacombe, Catherine
    Mayeux, Patrick
    Bouscary, Didier
    Tamburini, Jerome
    BLOOD, 2012, 119 (07) : 1791 - 1792
  • [38] Gilteritinib as treatment for extra-medullary relapse of FLT3-ITD acute myeloid leukemia FLT3-ITD, after allogeneic haematopoietic stem cell transplantation
    Iannotta, R.
    Celentano, M.
    Marotta, S.
    Pedata, C. M.
    Riccardi, C.
    Migliaccio, I.
    Viola, A.
    Muggianu, S. M.
    Falco, C.
    Bovenzi, D.
    Ferrara, F.
    Picardi, A.
    LEUKEMIA RESEARCH REPORTS, 2022, 18
  • [39] Phase I/II Study of Quizartinib, Venetoclax, and Decitabine Triple Combination in FLT3-ITD Mutated AML
    Yilmaz, Musa
    Muftuoglu, Muharrem
    DiNardo, Courtney D.
    Kadia, Tapan M.
    Konopleva, Marina Y.
    Borthakur, Gautam
    Pemmaraju, Naveen
    Short, Nicholas J.
    Valero, Yesid Alvarado
    Maiti, Abhishek
    Masarova, Lucia
    Montalban-Bravo, Guillermo
    Jurisprudencia, Carissa
    Pike, Allison
    Loghavi, Sanam
    Patel, Keyur P.
    Tang, Guilin
    Matthews, Jairo
    Kornblau, Steven M.
    Jabbour, Elias
    Garcia-Manero, Guillermo
    Ravandi, Farhad
    Andreeff, Michael
    Daver, Naval
    BLOOD, 2023, 142
  • [40] FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations
    Seedhouse, Claire H.
    Pallis, Monica
    Grundy, Martin
    Shang, Shili
    Russell, Nigel H.
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 147 (05) : 653 - 661