A potentiometric, enantioselective membrane electrode for S-ramipril assay

被引:0
|
作者
Stefan, RI [1 ]
van Staden, JF
Baiulescu, GE
Aboul-Enein, HY
机构
[1] Univ Pretoria, Dept Chem, ZA-0002 Pretoria, South Africa
[2] Univ Bucharest, Fac Chem, Dept Analyt Chem, Bucharest, Romania
[3] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC03, Bioanalyt & Drug Dev Lab, Riyadh 11211, Saudi Arabia
来源
CHEMIA ANALITYCZNA | 1999年 / 44卷 / 3A期
关键词
potentiometric; enantioselective membrane electrode; S-ramipril; 2-hydroxy-3-trimethylammoniopropyl-beta-cyclodextrin (as chloride salt);
D O I
暂无
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil), impregnated with 10(-3) mol l(-1) 2-hydroxy-3-trimethyl-ammoniopropyl-beta-cyclodextrin (as chloride salt) solution, is proposed for S-ramipril assay. This sensor can be used reliably for the assay of S-ramipril as raw material (enantiopurity tests), as well as in its pharmaceutical formulations, in the concentration range from 1.80 x 10(-5) to 2.3 x 10(-1) mol l(-1),with a detection limit of 1 x 10-5 mol l(-1), and with an average recovery of 99.94% (RSD = 0.030%) (recovery test), employing the potentiometric technique. The enantioselectivity was determined versus D-proline. It was shown that L-proline is the only main interfering compound. The surface of the electrode can be regenerated by simply polishing it to obtain a fresh surface which is ready to be used in a new assay.
引用
收藏
页码:417 / 422
页数:6
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