Microalbuminuria in the US population: Third National Health and Nutrition Examination Survey

被引:323
|
作者
Jones, CA
Francis, ME
Eberhardt, MS
Chavers, B
Coresh, J
Engelgau, M
Kusek, JW
Byrd-Holt, D
Narayan, V
Herman, WH
Jones, CP
Salive, M
Agodoa, LY
机构
[1] Joslin Diabet Ctr, Div Genet & Epidemiol, Sect Genet & Epidemiol, Boston, MA 02215 USA
[2] Social & Sci Syst, Silver Spring, MD USA
[3] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Epidemiol, Hyattsville, MD 20782 USA
[4] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA
[5] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA
[6] Johns Hopkins Univ, Dept Biostat & Med, Baltimore, MD USA
[7] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA
[8] NIDDKD, Clin Trials Program, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA
[9] Univ Michigan, Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Ann Arbor, MI 48109 USA
[10] Univ Michigan, Med Ctr, Dept Epidemiol, Div Endocrinol & Metab, Ann Arbor, MI 48109 USA
[11] Assoc Black Cardiologists Inc, Epidemiol & Clin Trials Ctr, Atlanta, GA USA
[12] NHLBI, Div Epidemiol & Clin Applicat, Prevent Sci Res Grp, NIH, Bethesda, MD 20892 USA
[13] NIDDKD, End Stage Renal Dis Program, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA
[14] NIDDKD, Minor Hlth Program, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA
关键词
Third National Health and Nutrition Examination Survey (NHANES III); population survey; cross-sectional survey; prevalence; microalbuminuria (MA); proteinuria; albuminuria; random untimed urine; albumin-creatinine ratio (ACR); hypertension; diabetes;
D O I
10.1053/ajkd.2002.31388
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Microalbuminuria (MA) is associated with adverse health outcomes in diabetic and hypertensive adults. The prevalence and clinical significance of MA in nondiabetic populations is less clear. The purpose of this study was to generate national estimates of the prevalence of MA in the US population. Untimed urinary albumin concentrations (UACs) and creatinine concentrations were evaluated in a nationally representative sample of 22,244 participants aged 6 years and older. Persons with hematuria and menstruating or pregnant women were excluded from analysis. The percent prevalence of clinical proteinuria (UAC greater than or equal to 300 mg/L) was similar for males and females. However, the prevalence of MA (urinary albumin-creatinine ratio [ACR], 30 to 299 mg/g) was significantly lower in males (6.1%) compared with females (9.7%). MA prevalence was greater in children than young adults and increased continuously starting at 40 years of age. MA prevalence was greater in non-Hispanic blacks and Mexican Americans aged 40 to 79 years compared with similar-aged non-Hispanic whites. MA prevalence was 28.8% in persons with previously diagnosed diabetes, 16.0% in those with hypertension, and 5.1% in those without diabetes, hypertension, cardiovascular disease, or elevated serum creatinine levels. In adults aged 40+ years, after excluding persons with clinical proteinuria, albuminuria (defined as ACR 30 mg/g) was independently associated with older age, non-Hispanic black and Mexican American ethnicity, diabetes, hypertension, and elevated serum creatinine concentration. MA is common, even among persons without diabetes or hypertension. Age, sex, race/ethnicity, and concomitant disease contribute to the variability of MA prevalence estimates. (C) 2002 by the National Kidney Foundation, Inc.
引用
收藏
页码:445 / 459
页数:15
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