Synthesis of several 3-substituted 2-trifluoromethylindoles via Mannich reaction of 2-trifluoromethylindoles

被引：0

作者：

Miyashita, K ^{[1
]}

Kondoh, K ^{[1
]}

Tsuchiya, K ^{[1
]}

Miyabe, H ^{[1
]}

Imanishi, T ^{[1
]}

机构：

[1] OSAKA UNIV, FAC PHARMACEUT SCI, SUITA, OSAKA 565, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 05期

关键词：

2-trifluoromethylindole; Mannich reaction; synthesis; nucleophilic substitution;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 2-trifluoromethyl derivatives of biologically active indoles, tryptamine, indole-3-acetic acid, oxypertine and tryptophan,were synthesized starting from 2-trifluoromethylindoles by use of the Mannich reaction and subsequent nucleophilic substitution reaction as key steps, In this study, chemoselective hydrolysis and reductions of the nitrile group to the respective carboxylic acid, amine and aldehyde in the presence of the trifluoromethyl group were achieved.

引用

页码：932 / 935

页数：4

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