Isolation of oxymatrine from alkaloids of Sophora flavescens Ait. by H103 macroporous resin

被引：1

作者：

Li, Xia ^{[1
]}

Du, Ailing ^{[1
]}

Du, Aiqin ^{[1
]}

Wang, Yan ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250061, Peoples R China

来源：

ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5 | 2013年 / 634-638卷

关键词：

oxymatrine; Sophora flavescens Ait; macroporous resin;

D O I：

10.4028/www.scientific.net/AMR.634-638.403

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

An efficient and environment-friendly macroporous resin column chromatographic separation method has been developed for preparative isolation of oxymatrine from alkaloids of Sophora flavescens Ait. in the present study. The static adsorption ratios of nine macroporous resins were evaluated. The results demonstrate that H103 macroporous resin, showing high adsorption and desorption capacity, is suitable for separation of oxymatrine. The optimal parameters are obtained: the H103 resins are packed with ethanol, height-diameter ratio (H/D in short) of H103 resin-packed chromatogram column is 33:1, the elution program is 30% C2H5OH-25% NH4OH (115:1, v/v) at flow rate of 2.0 mL/min. After isolation on resin column chromatography, target compound is adequately separated from interferences; the purity of oxymatrine is increased to 91.53% by GC-MS analysis and the recovery yield of oxymatrine is 78.19%.

引用

页码：403 / 407

页数：5

共 38 条

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