IMPACT OF NEUROPEPTIDE SUBSTANCE P AN INFLAMMATORY COMPOUND ON ARACHIDONIC ACID COMPOUND GENERATION

被引：17

作者：

Nicoletti, M. ^{[1
]}

Neri, G. ^{[2
]}

Maccauro, G. ^{[3
]}

Tripodi, D. ^{[4
]}

Varvara, G. ^{[4
]}

Saggini, A. ^{[5
]}

Potalivo, G. ^{[6
]}

Castellani, M. L. ^{[7
]}

Fulcheri, M. ^{[8
]}

Rosati, M. ^{[9
]}

Toniato, E. ^{[7
]}

Caraffa, A. ^{[6
]}

Antinolfi, P. ^{[6
]}

Cerulli, G. ^{[6
]}

Pandolfi, F. ^{[10
]}

Galzio, R. ^{[11
]}

Conti, P. ^{[7
]}

Theoharides, T. C. ^{[12
]}

机构：

[1] Univ G dAnnunzio, Dept Neurosci & Imaging, Chieti, Italy

[2] Univ G dAnnunzio, ENT Div, Chieti, Italy

[3] Univ Cattolica Sacro Cuore, Orthoped Div, Rome, Italy

[4] Univ G dAnnunzio, Sch Dent, Chieti, Italy

[5] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[6] Univ Perugia, Orthoped Div, I-06100 Perugia, Italy

[7] Univ G dAnnunzio, Div Immunol, Chieti, Italy

[8] Univ G dAnnunzio, Dept Psychol, Chieti, Italy

[9] Santo Spirito Hosp, Gynecol Div, Pescara, Italy

[10] Univ Cattolica Sacro Cuore, Dept Med, Rome, Italy

[11] Univ LAquila, Dept Neurosurg, Laquila, Italy

[12] Tufts Univ, Sch Med, New England Med Ctr, Dept Physiol & Pharmacol, Boston, MA 02111 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2012年 / 25卷 / 04期

关键词：

substance P; interleukins; cytokines; inflammation; PITUITARY-THYROID AXIS; MAST-CELLS; IN-VITRO; CIRCADIAN RHYTHMICITY; BIOLOGICAL-ACTIVITIES; KAPPA-B; EXPRESSION; ALPHA; INFECTION; GROWTH;

D O I：

10.1177/039463201202500403

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.

引用

页码：849 / 857

页数：9

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