MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1

被引：104

作者：

Shi, Zhu-mei ^{[1
]}

Wang, Jing ^{[2
]}

Yan, Zhiping ^{[2
]}

You, Yong-ping ^{[1
]}

Li, Chong-yong ^{[2
]}

Qian, Xu ^{[2
]}

Yin, Yu ^{[2
]}

Zhao, Peng ^{[1
]}

Wang, Ying-ying ^{[1
]}

Wang, Xie-feng ^{[1
]}

Li, Ming-na ^{[3
]}

Liu, Ling-Zhi ^{[4
]}

Liu, Ning ^{[1
]}

Jiang, Bing-Hua ^{[1
,2
,4
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Pathol, Ctr Canc, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Pathol, Nanjing, Jiangsu, Peoples R China

[4] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

PLOS ONE | 2012年 / 7卷 / 03期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

CANCER CELLS; MICRORNAS; EXPRESSION; ACTIVATION; GLIOBLASTOMA; PATHWAY; VEGF; AKT; PCR; TUMORIGENESIS;

D O I：

10.1371/journal.pone.0032709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-128 expression levels were decreased in glioma, and identified p70S6K1 as a novel direct target of miR-128. Overexpression of miR-128 suppressed p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression, and attenuated cell proliferation, tumor growth and angiogenesis. Forced expression of p70S6K1 can partly rescue the inhibitory effect of miR-128 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future.

引用

页数：10

共 50 条

[41] P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2
Xiaoxiang Chen
Kaixuan Zeng
Mu Xu
Xiangxiang Liu
Xiuxiu Hu
Tao Xu
Bangshun He
Yuqin Pan
Huiling Sun
Shukui Wang
[J]. Cell Death & Disease, 10
[42] P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2
Chen, Xiaoxiang
Zeng, Kaixuan
Xu, Mu
Liu, Xiangxiang
Hu, Xiuxiu
Xu, Tao
He, Bangshun
Pan, Yuqin
Sun, Huiling
Wang, Shukui
[J]. CELL DEATH & DISEASE, 2019, 10 (2)
[43] Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth
Zhang, Eryun
Shi, Hailian
Yang, Li
Wu, Xiaojun
Wang, Zhengtao
[J]. ONCOLOGY REPORTS, 2017, 38 (01) : 359 - 367
[44] Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1
Carpenter, Richard L.
Jiang, Yue
Jing, Yi
He, Jun
Rojanasakul, Yon
Liu, Ling-Zhi
Jiang, Bing-Hua
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 414 (03) : 533 - 538
[45] Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma
Spaan, Ingrid
Timmerman, Laura M.
Kimman, Thomas
Slomp, Anne
Cuenca, Marta
van Nieuwenhuijzen, Niels
Moesbergen, Laura M.
Minnema, Monique C.
Raymakers, Reinier A.
Peperzak, Victor
[J]. BLOOD ADVANCES, 2021, 5 (12) : 2593 - 2607
[46] Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
Ji, Lijun
Wu, Mingfei
Li, Zeng
[J]. MOLECULES, 2018, 23 (08)
[47] Correlation of the AKT/mTOR/p70S6K1 pathway and phosphorylated vascular endothelial growth factor receptor 2 in human epithelial ovarian cancer
Trinh, X. B.
Tjalma, W. A. A.
Dirix, L. Y.
Vemeulen, P. B.
Van Den Eynden, G. G.
Van Laere, S. J.
Van Der Auwera, I.
van Dam, P. A.
[J]. EJC SUPPLEMENTS, 2007, 5 (04): : 313 - 313
[48] Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation
Yamamura, Junki
Ma, Sihui
Jia, Huijuan
Kato, Hisanori
[J]. FRONTIERS IN NUTRITION, 2022, 9
[49] Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis-involvement of the miR-145/p70S6K1/HIF1α axis in vivo and in vitro
Kim, Hyemee
Banerjee, Nivedita
Sirven, Maritza A.
Minamoto, Yasushi
Markel, Melissa E.
Suchodolski, Jan S.
Talcott, Stephen T.
Mertens-Talcott, Susanne U.
[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 43 : 107 - 115
[50] miR-363-3p inhibits tumor growth by targeting PCNA in lung adenocarcinoma
Wang, Yahong
Chen, Ting
Huang, Haili
Jiang, Yun
Yang, Lawei
Lin, Ziying
He, Huijuan
Liu, Tie
Wu, Bin
Chen, Jie
Kamp, David W.
Liu, Gang
[J]. ONCOTARGET, 2017, 8 (12) : 20133 - 20144

← 1 2 3 4 5 →