Prion Chemical Biology: On the Road to Therapeutics?

被引：0
|
作者：
Chen, Beining [1 ]
Thompson, Mark [1 ]
Louth, Jennifer [1 ]
Guo, Kai [2 ]
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 19期
基金：
英国工程与自然科学研究理事会;
关键词：
Quinacrine; antiprion; prion protein; drug discovery; indole; prion diseases; pyridine dicarbonitrile; thiazole; CREUTZFELDT-JAKOB-DISEASE; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; DOMINANT-NEGATIVE INHIBITION; BENZODIAZEPINE-RECEPTOR SITE; AFFECTS ABNORMAL PROPERTIES; FATAL FAMILIAL INSOMNIA; SYNTHETIC PRP PEPTIDES; AMPHOTERICIN-B DELAYS; PROTEIN-X BINDS; CONGO-RED;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.
引用
收藏
页码：2441 / 2464
页数：24
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