MicroRNAs as potential therapeutic targets in kidney disease

被引：25

作者：

Gomez, Ivan G. ^{[1
,2
,3
]}

Grafals, Monica ^{[4
,5
]}

Portilla, Didier ^{[6
]}

Duffield, Jeremy S. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Med, Div Nephrol, Seattle, WA 98195 USA

[2] Ctr Lung Biol, Dept Pathol & Med, Seattle, WA USA

[3] Inst Stem Cell & Regenerat Med, Seattle, WA USA

[4] Lahey Clin Med Ctr, Div Transplantat, Burlington, MA 01803 USA

[5] Tufts Univ, Boston, MA 02111 USA

[6] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72205 USA

来源：

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 2013年 / 112卷 / 05期

关键词：

chronic allograft disease; chronic kidney disease; kidney fibrosis; peroxisome proliferator activated receptor; reactive oxygen species;

D O I：

10.1016/j.jfma.2012.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One cornerstone of chronic kidney disease (CKD) is fibrosis, as kidneys are susceptible due to their high vascularity and predisposition to ischemia. Presently, only therapies targeting the angiotensin receptor are used in clinical practice to retard the progression of CKD. Thus, there is a pressing need for new therapies designed to treat the damaged kidney. Several independent laboratories have identified a number of microRNAs that are dysregulated inhuman and animal models of CKD. This review will explore the evidence suggesting that by blocking the activity of such dysregulated microRNAs, new therapeutics could be developed to treat the progression of CKD. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.

引用

页码：237 / 243

页数：7

共 50 条

[21] Therapeutic microRNAs in polycystic kidney disease
Yheskel, Matanel
Patel, Vishal
[J]. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2017, 26 (04): : 282 - 289
[22] MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?
Palideh, Abdolhakim
Vaghari-Tabari, Mostafa
Andevari, Ali Nosrati
Qujeq, Durdi
Asemi, Zatollah
Alemi, Forough
Otaghsara, Hemmatollah Rouhani
Rafieyan, Sona
Yousefi, Bahman
[J]. ADVANCED PHARMACEUTICAL BULLETIN, 2023, 13 (03) : 423 - 434
[23] MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease
Olson, Eric N.
[J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (239)
[24] MicroRNAs as Therapeutic Targets for Alzheimer's Disease
Di Meco, Antonio
Pratico, Domenico
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2016, 53 (02) : 367 - 372
[25] Non-Canonical Targets of MicroRNAs: Role in Transcriptional Regulation, Disease Pathogenesis and Potential for Therapeutic Targets
Ray, Aishwarya
Sarkar, Abhisek
Banerjee, Sounak
Biswas, Kaushik
[J]. MICRORNA, 2024, 13 (02) : 83 - 95
[26] MicroRNAs in Osteoclastogenesis and Function: Potential Therapeutic Targets for Osteoporosis
Ji, Xiao
Chen, Xiang
Yu, Xijie
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (03)
[27] MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis
Shi Jingsheng
Wei Yibing
Xia Jun
Wang Siqun
Wu Jianguo
Chen Feiyan
Huang Gangyong
Chen Jie
[J]. JOURNAL OF BONE AND MINERAL METABOLISM, 2015, 33 (01) : 1 - 8
[28] MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis
Shi Jingsheng
Wei Yibing
Xia Jun
Wang Siqun
Wu Jianguo
Chen Feiyan
Huang Gangyong
Chen Jie
[J]. Journal of Bone and Mineral Metabolism, 2015, 33 : 1 - 8
[29] MicroRNAs as therapeutic targets and their potential applications in cancer therapy
Cho, William C. S.
[J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (08) : 747 - 759
[30] What are microRNAs? Potential biomarkers and therapeutic targets in osteoporosis
Giner, M.
Montoya, M. J.
Vazquez, M. A.
Miranda, C.
Miranda, M. J.
Perez-Cano, R.
[J]. REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL, 2016, 8 (01) : 40 - 44

← 1 2 3 4 5 →