MicroRNAs as potential therapeutic targets in kidney disease

被引：25

作者：

Gomez, Ivan G. ^{[1
,2
,3
]}

Grafals, Monica ^{[4
,5
]}

Portilla, Didier ^{[6
]}

Duffield, Jeremy S. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Dept Med, Div Nephrol, Seattle, WA 98195 USA

[2] Ctr Lung Biol, Dept Pathol & Med, Seattle, WA USA

[3] Inst Stem Cell & Regenerat Med, Seattle, WA USA

[4] Lahey Clin Med Ctr, Div Transplantat, Burlington, MA 01803 USA

[5] Tufts Univ, Boston, MA 02111 USA

[6] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72205 USA

来源：

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 2013年 / 112卷 / 05期

关键词：

chronic allograft disease; chronic kidney disease; kidney fibrosis; peroxisome proliferator activated receptor; reactive oxygen species;

D O I：

10.1016/j.jfma.2012.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One cornerstone of chronic kidney disease (CKD) is fibrosis, as kidneys are susceptible due to their high vascularity and predisposition to ischemia. Presently, only therapies targeting the angiotensin receptor are used in clinical practice to retard the progression of CKD. Thus, there is a pressing need for new therapies designed to treat the damaged kidney. Several independent laboratories have identified a number of microRNAs that are dysregulated inhuman and animal models of CKD. This review will explore the evidence suggesting that by blocking the activity of such dysregulated microRNAs, new therapeutics could be developed to treat the progression of CKD. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.

引用

页码：237 / 243

页数：7

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