Regulation of SIRT6 protein levels by nutrient availability

被引：3

作者：

Kanfi, Yariv ^{[1
]}

Shalman, Ronnie ^{[1
]}

Peshti, Victoria ^{[1
]}

Pilosof, Shmuel N. ^{[1
]}

Gozlan, Yosi M. ^{[1
]}

Pearson, Kevin J. ^{[2
]}

Lerrer, Batya ^{[1
]}

Moazed, Danesh ^{[3
]}

Marine, Jean-Christophe ^{[4
]}

de Cabo, Rafael ^{[2
]}

Cohen, Haim Y. ^{[1
]}

机构：

[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

[2] NIA, Lab Expt Gerontol, NIH, Baltimore, MD 21224 USA

[3] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[4] Univ Ghent VIB, B-9000 Ghent, Belgium

来源：

FEBS LETTERS | 2008年 / 582卷 / 05期

关键词：

SIRT6; sirtuin; calorie restriction; nutrient availability;

D O I：

10.1016/j.febslet.2008.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：543 / 548

页数：6

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