Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

被引：172

作者：

Bryan, Marian C. ^{[1
]}

Dillon, Barry ^{[2
]}

Hamann, Lawrence G. ^{[3
]}

Hughes, Gregory J. ^{[4
]}

Kopach, Michael E. ^{[5
]}

Peterson, Emily A. ^{[6
]}

Pourashraf, Mehrnaz ^{[7
]}

Raheem, Izzat ^{[8
]}

Richardson, Paul ^{[9
]}

Richter, Daniel

Sneddon, Helen F. ^{[10
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

[2] AstraZeneca, Brixham Environm Lab, Brixham TQ5 8BA, Devon, England

[3] Novartis Inst BioMed Res, Cambridge, MA 02139 USA

[4] Merck, Rahway, NJ 07065 USA

[5] Eli Lilly & Co, Indianapolis, IN 46285 USA

[6] Amgen Inc, Cambridge, MA 02142 USA

[7] AstraZeneca, R&D Montreal, St Laurent, PQ H4S 1Z9, Canada

[8] Merck, West Point, PA 19486 USA

[9] Pfizer Global Res & Dev, San Diego, CA 92121 USA

[10] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 56卷 / 15期

关键词：

GREEN CHEMISTRY; PHARMACEUTICAL-INDUSTRY; ENZYMATIC REDUCTION; ORGANIC-SYNTHESIS; ROOM-TEMPERATURE; CROSS-COUPLINGS; DRUG DISCOVERY; SOLVENT; REPLACEMENT; PERSPECTIVE;

D O I：

10.1021/jm400250p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The medicinal chemistry subgroup of the American Chemical Society's Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of environmentally sustainable practices in medicinal chemistry with the aim of sharing best practices more widely and highlighting some potential future developments.

引用

页码：6007 / 6021

页数：15

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