Biological and physicochemical properties of two polysaccharides from the mycelia of Grifola umbellate

被引：25
|
作者：
Bi, Yunpeng [1 ]
Miao, Ye [2 ,3 ]
Han, Yan [4 ]
Xu, Jian [5 ]
Wang, Qing [6 ]
机构：
[1] Fourth Mil Med Univ, Dept Prosthodont, Sch Stomatol, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Sch Stomatol, Dept Oral Biol, Xian 710038, Peoples R China
[3] 198th Mil Hosp, Dept Oncol, Chen Zhou 423000, Peoples R China
[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Pharm, Xian 710038, Shaanxi, Peoples R China
[5] Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Peoples R China
[6] Fourth Mil Med Univ, Tangdu Hosp, Dept Gen Surg, Xian 710038, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 95卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Grifola umbellate; Mycelia; Polysaccharide; Antioxidant; Anti-hepatoma; Immunomodulatory; WATER-SOLUBLE POLYSACCHARIDE; ANTI-TUMOR ACTIVITY; ANTIOXIDANT ACTIVITIES; FR PILAT; GLUCANS; EXTRACT; GROWTH; DRUGS;
D O I：
10.1016/j.carbpol.2013.03.002
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In the present study, we firstly reported the antioxidant, antitumor and immunomodulatory effects of two polysaccharides (GUMP-1-1 and GUMP-1-2) isolated from Grifola umbellata mycelia. Chemical analysis indicated that two polysaccharide fractions contained different content of neutral sugar, uronic acid and protein, as well as varying monosaccharide compositions and average molecular weight. We found that they could significantly inhibit the growth of H22 implanted tumor and enhance the spleen index and splenocyte proliferation of H22 tumor-bearing mice. In addition, GUMP-1-2 had the stronger free radicals scavenging and ferrous ion chelating abilities than GUMP-1-1 in vitro. These results indicated that antitumor activity of two purified polysaccharides might be achieved by improving immune response and the different chemical composition and average molecular weight could affect their antitumor, antioxidant and immunomodulatory activities. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：740 / 745
页数：6
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