Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity

被引：128

作者：

Paul, Kamaldeep ^{[1
]}

Bindal, Shweta ^{[1
]}

Luxami, Vijay ^{[1
]}

机构：

[1] Thapar Univ, Sch Chem & Biochem, Patiala 147004, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 12期

关键词：

Coumarin; Benzimidazole; Hybrids; Anticancer agents; Molecular docking; VIRUS NS5B POLYMERASE; NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; IN-VITRO; ANTITUMOR-ACTIVITY; DERIVATIVES; INHIBITORS; DESIGN; POTENT; ACID;

D O I：

10.1016/j.bmcl.2012.12.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3667 / 3672

页数：6

共 50 条

[31] Some new indole-coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
Kamath, Pooja R.
Sunil, Dhanya
Ajees, A. Abdul
Pai, K. S. R.
Das, Shubhankar
[J]. BIOORGANIC CHEMISTRY, 2015, 63 : 101 - 109
[32] Coumarin - benzimidazole hybrids: A review on diverse synthetic strategies
Arya, C. G.
Chandrakanth, Munugala
Fabitha, K.
Thomas, Neethu Mariam
Pramod, Rakendu N.
Gondru, Ramesh
Banothu, Janardhan
[J]. RESULTS IN CHEMISTRY, 2022, 4
[33] Natural coumarin and methoxyacrylate hybrids: Anticancer activity, SAR, and mode of action studies
Guan, Aiying
Liu, Changling
Zhang, Mingxing
Yang, Fan
Xie, Yong
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[34] Anticancer Activity Study of Chromone and Coumarin Hybrids using Electrical Impedance Spectroscopy
Bouhenna, Mustapha M.
Mameri, Nabil
Perez, Monica, V
Talhi, Oualid
Bachari, Khaldoun
Silva, Artur M. S.
Luyten, Walter
[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2018, 18 (06) : 854 - 864
[35] A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+
Djemoui, Amar
Naouri, Abdelkader
Ouahrani, Mohammed Ridha
Djemoui, Djamila
Lahcene, Souli
Lahrech, Mokhtar Boualem
Boukenna, Leila
Albuquerque, Helio M. T.
Saher, Liza
Rocha, Djenisa H. A.
Monteiro, Fatima Liliana
Helguero, Luisa A.
Bachari, Khaldoun
Talhi, Oualid
Silva, Artur M. S.
[J]. JOURNAL OF MOLECULAR STRUCTURE, 2020, 1204
[36] Anticancer activity and DNA binding property of the trimers of triphenylethylene-coumarin hybrids
Zhang, Li
Yao, Yu-Chao
Gao, Meng-Ying
Rong, Rui-Xue
Wang, Ke-Rang
Li, Xiao-Liu
Chen, Hua
[J]. CHINESE CHEMICAL LETTERS, 2016, 27 (11) : 1708 - 1716
[37] Anticancer activity and DNA binding property of the trimers of triphenylethylene-coumarin hybrids
Li Zhang
Yu-Chao Yao
Meng-Ying Gao
Rui-Xue Rong
Ke-Rang Wang
Xiao-Liu Li
Hua Chen
[J]. Chinese Chemical Letters, 2016, 27 (11) : 1708 - 1716
[38] Acetylcholine Inhibitory Study of Novel Thio Linked Coumarin-Benzimidazole Derivatives: Design, Synthesis, Computational, and In Silico Molecular Docking Studies
Nayaka, T. H. Maruthi
Pushpavathi, Itte
Nagesh, Y. R.
[J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2024, 50 (01) : 211 - 226
[39] Recent Progress of Benzimidazole Hybrids for Anticancer Potential
Akhtar, Jawaid
Yar, Mohammad Shahar
Sharma, Vinod Kumar
Khan, Ahsan Ahmed
Ali, Zulphikar
Haider, M. D. Rafi
Pathak, Ankita
[J]. CURRENT MEDICINAL CHEMISTRY, 2020, 27 (35) : 5970 - 6014
[40] Coumarin-containing hybrids and their anticancer activities
Zhang, Longfei
Xu, Zhi
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 181

← 1 2 3 4 5 →